Pregnancy alters the disposition and exposure to multiple drugs indicated for pregnancy-related complications.Previous in vitro studies have shown that pregnancy-related hormones (PRHs) alter the expression and function of certain cytochrome P450s (CYPs) in human hepatocytes.However, the impact of PRHs on hepatic concentrations of Toasters non-CYP
Androgen receptor (AR), an important target in the current androgen derivation therapy, plays a critical role in the development and progress of prostate cancer (PCa).Nonsteroidal antiandrogens, such as enzalutamide and bicalutamide, are commonly used in clinic to treat PCa.Though they are very effective at the beginning, drug resistance problem ap
An airport ferry vehicle is a ground service vehicle used to transfer passengers between the far apron and the terminal.The travel time of ferry tasks in the airport ferry network is an important decision-making basis for ferry vehicle scheduling.This paper presents a graph-based method to mine the travel time between nodes in the airport ferry net