IMPACT OF PREGNANCY RELATED HORMONES ON DRUG METABOLIZING ENZYME AND TRANSPORT PROTEIN CONCENTRATIONS IN HUMAN HEPATOCYTES

Impact of pregnancy related hormones on drug metabolizing enzyme and transport protein concentrations in human hepatocytes

Pregnancy alters the disposition and exposure to multiple drugs indicated for pregnancy-related complications.Previous in vitro studies have shown that pregnancy-related hormones (PRHs) alter the expression and function of certain cytochrome P450s (CYPs) in human hepatocytes.However, the impact of PRHs on hepatic concentrations of Toasters non-CYP

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